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The Biology of Glioblastoma In this section, we discuss how GBMs characteristic intra-tumoral heterogeneity, as well as the local and systemic immunosuppressive environment that it induces, has limited the development of effective therapies

In diabetes and obesity, accelerated formation of an enlarged necrotic core is likely instigated by defective macrophage insulin signaling (176) and saturated fatty acids (177,178), which are potent inducers of ER stress